Potential Therapeutic Application
|Source||Umbilical cord lining|
|Types of stem cells||Mesenchymal stem cells (MSCs)||Epithelial stem cells (EpSCs)|
Potential Treatment for
HSCs engraftment support
Wounds/soft tissue repair
Today, more than 190 clinical trials1 are on-going worldwide to uncover the potential of MSCs. Thus far, encouraging results have been published; stem cell treatments have been proven safe and capable of repairing damage caused by stroke and heart disease. MSCs have also been used in combination with HSCs as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications2.
Although there is evidence that MSCs can be changed to certain types of Epithelial cells, the cells cannot be changed into Epithelial stem cells (EpSCs). The difference between Epithelial stem cells and Epithelial cells is that Epithelial stem cells can differentiate into all different epithelial cell types such as skin, cornea, lining of the gut, etc. on demand. Whereas, (non-stem) Epithelial cells have already reached terminal differentiation so the cells cannot be further changed into different Epithelial cell types when needed. Thus, MSCs and EpSCs cannot be replaced by each other.
1 ClinicalTrials.gov. Accessed on 4 January 2012. (http://www.clinicaltrials.gov/ct2/results?term=mesenchymal+stem+cells)
2 Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.
Worldwide researches on diseases treated with MSCs by various Universities or Research Institutions:
|Diseases||Name of universities or research Institions|
|Stroke||University Hospital, Grenobe, France|
|Spinal Cord Injury||
|Amylotrophic Lateral Sclerosis||Hadassah Medical Organization, Israel|
|Parkinson's Disease||Jaslok Hospital and Research Centre, India|
|Multiple System Atrophy||Yonsei University, South Korea|
|Liver Disease||Cytori Therapeutics, U.S.|
|Diabetic Foot Ulcer||