Diseases Treated with Stem Cells and its Potential Applications

 

Diseases Treated with Stem Cells

Stem cells are at the forefront of one of the most fascinating and revolutionary areas of medicine today. Doctors recognize that stem cells have the potential to help treat numerous diseases by generating healthy new cells and tissue.

As a parent, you want to protect your family. At your baby’s birth, you have the unique opportunity to safeguard the health of the ones you love by storing your newborn child’s cord blood stem cells.

Stem cells in the blood of your baby’s umbilical cord have the potential to be used in the treatment of many diseases today. Stem cells could be used to treat haematopoietic and genetic disorders. In a cord blood transplant, stem cells are infused into a patient’s bloodstream where they go to work - healing and repairing damaged cells and tissue. With the successful engraftment of the stem cells, the patient’s blood and immune system are regenerated.

There are a wide range of diseases that are treatable with stem cells derived from cord blood and other sources of similar type of stem cells (Haematopoietic Stem Cell), like bone marrow and peripheral blood, including stem cell disorders, acute and chronic forms of leukemia, myeloproliferative disorders, and many more.

In addition to the host of conditions that can now be treated, it is the potential of stem cell treatments that holds the most excitement as research continues to uncover new possibilities. The potential and efficacy of treating diseases with stem cells are real.

Diseases Treated with Stem Cells

The following is a list of some of the diseases that have been treated with cord blood and other sources of similar type of stem cells (Haematopoietic Stem Cell), like bone marrow and peripheral blood. Stem cell therapies continue to change and evolve quickly.

BLOOD CANCERS

  • Acute Myelogenous Leukaemia
  • Acute Lymphoblastic Leukaemia
  • Chronic Myelogenous Leukaemia
  • Histiocytic Neoplasms
  • Other Myeloproliferative Neoplasms
  • Myelodysplastic syndrome
  • Multiple Myeloma
  • Plasma Cell Leukaemia
  • Systemic Mastocytosis
  • Waldenstrom’s Macroglobulinemia

SOLID TUMORS

  • Hodgkin Lymphoma
  • Non-Hodgkin Lymphoma
  • Langerhans' Cell Histiocytosis
  • Neuroblastoma
  • Retinoblastoma

NON-MALIGNANT BLOOD DISORDERS

  • Aplastic Anaemia
  • Chediak-Higashi Syndrome
  • Congenital Dyserythropoietic Anaemia
  • Diamond-Blackfan Syndrome
  • DiGeorge Syndrome
  • Evans Syndrome
  • Fanconi's Anaemia
  • Glanzmann'sThrombasthenia
  • Gunther’s Disease (erythropoietic porphyria)
  • Hereditary BM failure syndromes
  • Hemophagocytic Lymphohistiocytosis
  • Leukocyte Adhesion Deficiency
  • Paroxysmal Nocturnal Hemoglobinuria
  • Pure Red Cell Aplasia
  • Sickle Cell Anaemia
  • Thalassemia Major

IMMUNODEFICIENCY DISORDERS

  • Chronic Granulomatous Disease
  • Common Variable Immunodeficiency
  • Cartilage-Hair Hypoplasia
  • Reticular Dysgenesis
  • Severe Combined Immune Deficiency (SCID)
  • Shwachman-Diamond Syndrome
  • Wiskott-Aldrich Syndrome

METABOLIC DISORDERS

  • Adrenoleukodystrophy
  • Gaucher's Disease
  • Hurler Syndrome
  • Hunter’s Syndrome
  • Krabbe Disease
  • Lesch-Nyhan Syndrome
  • Maroteaux-Lamy Syndrome
  • Metachromatic leukodystrophy
  • Osteopetrosis
  • Sly Syndrome, Beta-Glucuronidase Deficiency
  • Wolman Disease

The successful application of cord blood stem cells is dependent on the condition of each individual patient. Banking cord blood does not guarantee that the cells will provide a cure or be applicable in every situation. The eventual use of the cord blood can only be determined by the treating physician. Though some of the conditions listed here may be treated with the patient’s own cord blood (autologous cord blood), it may not be suitable to treat genetic diseases. In such cases, a matching cord blood from a sibling may be used. However, there is no guarantee that the cord blood will be a match for every family member or will provide a cure for every condition. Please consult your treating physician for further advice.

Clinical Trials

With the advancement of stem cell* research, the potential for future use of stem cell grows.

Below is a list of diseases currently under Clinical Trials. These are diseases for which stem cell* treatments appear to be beneficial, but have not been adopted as standard therapy. For some of these diseases, stem cell transplants only slow the progression of the disease, but do not produce a cure. For other diseases, stem cell treatments may help effect a cure, but further research is needed to determine the best candidate patients for stem cell therapy, the optimum stem cell dosage, the optimum method of cell delivery, etc.

For some patients, clinical research trials represent an avenue for receiving promising new therapies that would not otherwise be available. Patients with difficult to treat or currently "incurable" diseases, such as AIDS or certain types of cancer, may want to pursue participation in clinical research trials if standard therapies are not effective. Clinical research trials are sometimes lifesaving.

For the latest information, please visit www.clinicaltrials.gov

  • Autism
  • Brain Tumor
  • Cartilage Repair
  • Cleft Palate Repair (Alveolar)
  • Cerebral palsy
  • Crohn’s disease
  • Critical Limb Ischemia
  • Diabetes Type 1
  • Epidermolysis Bullosa
  • Ewing Sarcoma
  • Graft-versus-Host Disease (GvHD)
  • Hypoxic Ischemic Encephalopathy (HIE)
  • Hearing Loss
  • HIV
  • Ischemic Stroke
  • Lupus
  • Multiple Sclerosis
  • Myocardial Infarction
  • Ovarian Cancer
  • Rheumatoid Arthritis
  • Spinal cord injury
  • Scleroderma
  • Testicular Tumour

Experimental Treatments

These are randomised controlled trials conducted in a scientific laboratory involving in-vitro (test tube or cell culture) and in-vivo (animal) work.

The experimental trials are in place to assist and to decide whether they have scientific merit for further development / progression to clinical trials.

  • Alzheimer's Disease
  • Amyotrophic lateral sclerosis
  • Congenital hydrocephalus
  • Huntington's Disease
  • Liver cirrhosis
  • Parkinson's Disease
  • Traumatic Brain Injury
Reference:

The above list of diseases is a compilation from the above websites and other sources such as medical literatures and journals. Kindly approach us at (02) 470-1735 or This email address is being protected from spambots. You need JavaScript enabled to view it. to request for a particular medical journal / literature.

*Stem cells mentioned here comprises of other cell lines such as Mesenchymal stem cells & etc. The clinical trials and experimental treatments listed above may be using other lines of stem cells, and not only Haematopoietic stem cells.

DCR No. 2148 Version C, May 2014

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