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Stem Cell Banking
Stem Cell Banking

Diseases Treated with Stem Cells and its Potential Applications

Stem cells are at the forefront of one of the most fascinating and revolutionary areas of medicine today. Doctors recognize that stem cells have the potential to help treat numerous diseases by generating healthy new cells and tissue. As a parent, you want to protect your family. At your baby’s birth, you have the unique opportunity to safeguard the health of the ones you love by storing your newborn child’s umbilical cord blood and umbilical cord lining stem cells.

Cord Blood Stem Cells

Stem cells in the blood of your baby’s umbilical cord have the potential to be used in the treatment of many diseases today. Stem cells could be used to treat hematopoietic and genetic disorders. In a stem cell transplant, umbilical cord stem cells are infused into a patient’s bloodstream where they go to work - healing and repairing damaged cells and tissue. With the successful engraftment of the stem cells, the patient’s blood and immune system are regenerated.

The following is a list of some of the diseases that have been treated with cord blood and other sources of similar type of stem cells (Hematopoietic Stem Cell), like bone marrow and peripheral blood. Stem cell therapies continue to change and evolve quickly.

There are a wide range of diseases that are treatable with Hematopoietic Stem Cells (HSCs) from umbilical cord blood, bone marrow, and peripheral blood such as stem cell disorders, acute and chronic forms of leukemia, myeloproliferative disorders, and many more. Stem cell therapies continue to change and evolve quickly.

Umbilical Cord Blood Stem Cells

Umbilical cord blood stem cells can be use to treat more than 80 diseases.

Blood Cancers

  • Acute Biphenotypic Leukaemia
  • Acute Lymphoblastic Leukaemia
  • Acute Myelogenous Leukaemia
  • Acute Undifferentiated Leukaemia
  • Chronic Myelogenous Leukaemia
  • Chronic Lymphocytic Leukaemia
  • Juvenile Myelomonocytic Leukaemia
  • Juvenile Chronic Myelogenous Leukaemia
  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia
  • Essential Thrombocythemia
  • Polycythemia Vera
  • Refractory Anaemia
  • Refractory Anaemia with Excess Blasts
  • Refractory Anaemia with Excess Blasts in Transformation
  • Refractory Anaemia with Ringed Sideroblasts (Sideroblastic Anaemia)
  • Chronic Myelomonocytic Leukaemia
  • Multiple Myeloma
  • Plasma Cell Leukaemia
  • Waldenstrom’s Macroglobulinemia
  • Histiocytic Neoplasms

Solid Tumors

  • Hodgkin Lymphoma
  • Langerhans' Cell Histiocytosis
  • Neuroblastoma
  • Non Hodgkin Lymphoma (Burkitt’s Lymphoma)
  • Retinoblastoma
  • Medulloblastoma
  • Wilms Tumor

Non Malignant Blood Disorders

  • Aplastic Anaemia
  • Congenital Dyserythropoietic Anaemia
  • Fanconi’s Anaemia
  • Paroxysmal Nocturnal Hemoglobinuria
  • Diamond Blackfan Syndrome
  • Dyskeratosis Congenita
  • Pearson’s Syndrome
  • Shwachman Diamond Syndrome
  • Pure Red Cell Aplasia
  • Sickle Cell Anaemia
  • Beta Thalassemia Major/Cooley’s Anaemia
  • Congenital Amegakaryocytosis Thrombocytopenia
  • Glanzmann’s Thrombasthenia

Immune Disorders

  • Bare Lymphocyte Syndrome
  • Omenn Syndrome
  • Reticular Dysgenesis
  • Neutrophil Actin Deficiency
  • SCID with Adenosine Deaminase Deficiency (ADA SCID)
  • SCID which is X linked
  • SCID with absence of T & B Cells
  • SCID with absence of T Cells, Normal B Cells
  • Kostmann Syndrome (Infantile Genetic Agranulocytosis)
  • Myelokathexis
  • Chediak Higashi Syndrome
  • Chronic Granulomatous Disease
  • Cartilage Hair Hypoplasia
  • Gunther’s Disease (Congenital Erythropoietic Protoporphyria)
  • Systemic Mastocytosis
  • Common Variable Immunodeficiency
  • DiGeorge Syndrome
  • Evans Syndrome
  • Hemophagocytic Lymphohistiocytosis
  • IKK Gamma Deficiency (NEMO Deficiency)
  • IPEX Syndrome
  • Leukocyte Adhesion Deficiency
  • Wiskott Aldrich Syndrome
  • X linked Lymphoproliferative Disease (Duncan’s Syndrome)
  • X linked Hyper IgM Syndrom
  • Ataxia-Telangiectasia

Metabolic Disorders

  • Adrenoleukodystrophy
  • Krabbe Disease (Globoid Cell Leukodystrophy)
  • Metachromatic leukodystrophy
  • Pelizaeus-Merzbacher Disease
  • Alpha Mannosidosis
  • Gaucher’s Disease
  • Niemann Pick Disease
  • Sandhoff Disease
  • Wolman Disease
  • Hunter Syndrome
  • Hurler Syndrome
  • Maroteaux Lamy Syndrome
  • Mucolipidosis II (I-cell Disease)
  • Morquio Syndrome
  • Sanfilippo Syndrome
  • Scheie Syndrome
  • Sly Syndrome (beta glucuronidase deficiency)

Other Metabolic Disorders

  • Lesch–Nyhan Syndrome
  • Osteopetrosis
  • Hermansky-Pudlak Syndrome

The successful application of umbilical cord blood stem cells is dependent on the condition of each individual patient. Banking umbilical cord blood does not guarantee that the cells will provide a cure or be applicable in every situation. The eventual use of the umbilical cord blood can only be determined by the treating physician. Though some of the conditions listed here may be treated with the patient’s own umbilical cord blood (autologous cord blood), it may not be suitable to treat genetic diseases. In such cases, a matching umbilical cord blood from a sibling may be used. However, there is no guarantee that the umbilical cord blood will be a match for every family member or will provide a cure for every condition. Please consult your treating physician for further advice.

In addition to the host of conditions that can now be treated, it is the potential of stem cell treatments that holds the most excitement as research continues to uncover new possibilities. The potential and efficacy of treating diseases with stem cells are real.

Clinical Trials

With the advancement of stem cell* research, the potential for future use of stem cell grows. Below is a list of diseases currently under Clinical Trials. These are diseases for which stem cell* treatments appear to be beneficial, but have not been adopted as standard therapy. For some of these diseases, stem cell transplants only slow the progression of the disease, but do not produce a cure. For other diseases, stem cell treatments may help effect a cure, but further research is needed to determine the best candidate patients for stem cell therapy, the optimum stem cell dosage, the optimum method of cell delivery, etc.

For some patients, clinical research trials represent an avenue for receiving promising new therapies that would not otherwise be available. Patients with difficult to treat or currently "incurable" diseases, such as AIDS or certain types of cancer, may want to pursue participation in clinical research trials if standard therapies are not effective. Clinical research trials are sometimes lifesaving.

For the latest information, please visit www.clinicaltrials.gov

  • Alzheimer’s Disease
  • Amyotrophic Lateral Sclerosis
  • Autism
  • Brain Tumour
  • Cardiomyopathy
  • Cartilage repair
  • Cerebral palsy
  • Cleft Palate Repair (Alveolar)
  • Compartment Syndrome (Battlefield Trauma)
  • Critical Limb Ischemia
  • Crohn's disease
  • Diabetes Type 1
  • Epidermolysis Bullosa
  • Ewing Sarcoma
  • Graft versus Host Disease (GvHD)
  • Hearing Loss (acquired sensorineural)
  • HIV
  • Huntington’s Disease
  • Hypoplastic Left Heart Syndrome
  • Hypoxic Ischemic Encephalopathy (HIE)
  • Ischemic Heart Disease
  • Ischemic Stroke
  • Kidney plus stem cell transplant
  • Liver cirrhosis
  • Lupus
  • Multiple Sclerosis
  • Myocardial Infarction
  • Open cardiac surgery for congenital heart diseases
  • Ovarian Cancer (Link to clinical trials)
  • Parkinson’s Disease
  • Rhabdomyosarcoma
  • Rheumatoid Arthritis
  • Scleroderma
  • Spinal cord injury
  • Testicular Tumour
  • Tissue Engineered Vascular Grafts for cardiac defects
  • Traumatic Brain Injury

Umbilical Cord Lining Stem Cells

Today, more than 600 clinical trials1 are on-going worldwide to uncover the potential of Mesenchymal Stem Cells (MSCs). Thus far, encouraging results have been published; stem cell treatments have been proven safe and capable of repairing damage caused by stroke and heart disease. MSCs have also been used in combination with Hematopoietic Stem Cells (HSCs) as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications2.

Although there is evidence that MSCs can be changed to certain types of Epithelial Cells, the cells cannot be changed into Epithelial Stem Cells (EpSCs). The difference between Epithelial stem cells and Epithelial cells is that Epithelial stem cells can differentiate into all different epithelial cell types such as skin, cornea, lining of the gut, etc. on demand. Whereas, (non-stem) Epithelial cells have already reached terminal differentiation so the cells cannot be further changed into different Epithelial cell types when needed. Thus, MSCs and EpSCs cannot be replaced by each other.


1 ClinicalTrials.gov. Accessed on 13 August 2017. (http://www.clinicaltrials.gov/ct2/results?term=mesenchymal+stem+cells)
2 Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.


Umbilical Cord Lining

Potential Therapeutic Application using MSCs and EpSCs

Mesenchymal Stem Cells (MSCs)

  • Stroke
  • Heart Failure
  • Alzheimer’s Disease
  • Parkinson’s Disease
  • Spinal Cord Injury
  • Orthopaedic indications (bone, cartilage, tendon repair)
  • Liver Failure
  • Autism
  • Shorten time of engraftment
  • Reduce immune system complications
  • HIV
  • Type 1 diabetes
  • Graft versus host disease (GvHD)

Epithelial Stem Cells (EpSCs)

  • Skin Wounds
  • Ocular Surface Disorders
  • Persistent Epithelial Defect
  • Replacement of Insulin-Producing Cells for Diabetic Patients
  • Haemophilia

MSCs Research

Worldwide researches on diseases treated with MSCs by various Universities or Research Institutions
DiseasesName of universities or research Institions
Stroke
  • University Hospital, Grenobe, France
Spinal Cord Injury
  • Cairo University, Egypt
  • Chinese University of Hong Kong
Multiple Sclerosis
  • Spain-Carlos Health Institute
  • University of Cambridge, U.K.
  • Cleveland Clinic, U.S.
Amylotrophic Lateral Sclerosis
  • Hadassah Medical Organization, Israel
Parkinson's Disease
  • Jaslok Hospital and Research Centre, India
Multiple System Atrophy
  • Yonsei University, South Korea
Liver Disease
  • Cytori Therapeutics, U.S.
Diabetic Foot Ulcer
  • Third Military Medical University, China
  • Washington DC Veterans Medical Centre, U.S.
  • Ruhr-University Bochum, Germany
Diabetes
  • FuZhou General Hospital, China
  • Uppsala University, Sweden


Reference:

The above list of diseases is a compilation from the aforementioned websites and other sources such as medical literatures and journals. Kindly approach us at (02) 470-1735/(02) 332-1888 or This email address is being protected from spambots. You need JavaScript enabled to view it. to request for a particular medical journal / literature.

*Stem cells mentioned here comprises of other cell lines such as Mesenchymal stem cells. The clinical trials and experimental treatments listed above may be using other lines of stem cells, and not only hematopoietic stem cells.

DCR No. 2770 Version E, QR 8.1 8 5 e, July 2016

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